Effects of Different Hypoglycemic Drugs on QT Interval Dispersion in Patients with Type 2 Diabetes Mellitus / 中国药房

ABSTRACT

OBJECTIVE:To investigate the effects of different kinds of hypoglycemic drugs on the QT interval dispersion in patients with type 2 diabetes mellitus. METHODS: The differences of QT interval dispersion (QTd) and corrected QT interval dispersion (QTcd) in 318 patients with type 2 diabetes (of which, 129 were assigned to receive insulin, 110 glibenclamide and 79 metformin) and 33 healthy volunteers (normal control) were compared. RESULTS: The QTd and QTcd were all significantly higher in glibenclamide group than in the other three groups(P0.05). CONCLUSION: The results suggest that glibenclamide and insulin may increase the QTd and QTcd in patients with type 2 diabetes.