Effects of Rhizoma Sparganii and Rhizoma Curcumae on the Angiogenesis of Newly Born Tissue in Artificial Sponge in Rats / 中国药房
China Pharmacy
;
(12)2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-530885
ABSTRACT
OBJECTIVE:
To explore the inhibitory effects and mechanism of Rhizoma Sparganii and Rhizoma Curcumae on the angiogenesis of new granulation tissue in sponge.METHODS:
The experimental endometriosis in female rats was established with sponge implantation.The effects of Rhizoma Sparganii and Rhizoma Curcumae on the angiogenesis of new granulation tissue in sponge were observed after intragastric medication for 2 consecutive weeks.The staining of endothelial cell specific Ⅷ factor and vascular endothelial cell growth factor(VEGF) was carried out by immunohistochemistry method.The expression of VEGF mRNA was detected by RT-PCR assay.RESULTS:
In rats receiving high dosage of Rhizoma Sparganii and Rhizoma Curcumae(SC),the area of new granulation tissue in sponge,the number of blood vessels,the expression of VE-GF and VEGF mRNA were all significantly lower than in model group(P
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2005
Tipo de documento:
Artigo
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