Aerosol Inhalation of Sodium Houttuyfonate Injection for Treatment of Pneumonia:A Systematic Review / 中国药房

ABSTRACT

OBJECTIVE:To evaluate the effectiveness and safety of an aerosol inhalation of Sodium Houttuyfonate injection in accessory treatment of pneumonia.METHODS:Biomedical databases,including Medline,EMbase,The Cochrane Central Register of Controlled Trials,CBM-disk and CNKI were searched.Randomized controlled trials(RCTs) and quasi-RCTs that compare aerosol inhalation of Sodium Houttuyfonate injection with placebo or other aerosol inhalation regimens were collected.A critical quality assessment and Meta-analysis were performed for included studies.RESULTS:Six RCTs were included and all of them were carried out in China.None of the trials described the method of randomization,allocation concealment,blind,and follow-up.With Junci scales,6 trials scored C degree.Compared with the control group,aerosol inhalation of Sodium Houttuyfonate injection showed significantly higher total improvement rate.We didn't find any RCTs describing the safety of Sodium Houttuyfonate injection aerosol inhalation.CONCLUSION:Because of the low quality of RCTs on Sodium Houttuyfonate injection aerosol inhalation for pneumonia and the lack of RCTs describing the safety of Sodium Houttuyfonate injection aerosol inhalation,no reliable conclusion can be drawn from our Meta-analysis about its efficacy and safety.Well-designed RCTs are urgently needed to evaluate the value and safety of aerosol inhalation of Sodium Houttuyfonate injection in treating pneumonia.