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Formula Optimization of Piribedil Hydrochloride Oral-Disintegrating Tablets / 中国药房
China Pharmacy ; (12)2005.
Artigo em Chinês | WPRIM | ID: wpr-530905
ABSTRACT

OBJECTIVE:

To optimize the formula of piribedil hydrochloride orally disintegrating tablets and to investigate their related indexes.

METHODS:

Taking the contents of crospovidone(PVP XL)(disintegrating agent),amylum pregelatinisatum(loading agent) and Gum Acacia(glidant) as factors,the disintegrating time(td),the wet time(t) and the suspend stability(?A) as the evaluate indexes to carry on the orthogonal experimental to optimize the formula.The dissolution curve of the optimized formula was drawn.

RESULTS:

The optimized formula for the piribedil hydrochloride orally disintegrating tablets were as followsthe contents of crospovidone(PVP XL),amylum pregelatinisatum and Gum Acacia were 15%,20%,and 15% respectively.The prepared orally disintegrating tablets disintegrated completely within 30s and dissolved basically within 2min.

CONCLUSION:

The prepared preparation can meet the related standards specified of China Pharmacopeia.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: China Pharmacy Ano de publicação: 2005 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: China Pharmacy Ano de publicação: 2005 Tipo de documento: Artigo