Preparation of Cefuroxime Axetil Bitter-masked Pellets / 中国药房

ABSTRACT

OBJECTIVE:To prepare bitter masked-pellets of cefuroxime axetil.METHODS:Cefuroxime axetil pellets were prepared by means of powder layering with the centrifugal granulation equipment,cefuroxime axetil pellets were coated in a fluid-bed equipment and the bitter was masked,and the dissolution of the preparation was determined.RESULTS:The recovery of the pellets between 40～50 meshes and yield rates was 89.5%;the drug content was 6.29% and the dissolution was 80% at 45 min.CONCLUSION:Bitter masked-pellets of cefuroxime axetil can be prepared by the fluid-bed coating method.