Inhibitory Effect of Octritide Combined 5-Fluorouracil on the Proliferation of Human Colonic Cancer Cell Line SW480 / 中国药房

ABSTRACT

OBJECTIVE:To explore the inhibitory effects of octritide alone or in combination with 5-fluorouracil on the proliferation of human colonic cancer cell line SW480.METHODS:MTT assay was used to detect the absorbance after treatment with octreotide at different concentrations(10-7～10-10 mol?L-1) alone or in combination with 5-fluorouracil on the proliferation of SW480 cells,then the inhibition ratio on SW480 cells was derived.RESULTS:At a concentration of 10-10 mol?L-1,octreotide exhibited a highest inhibition ratio on colonic cancer cell line SW480,at a concentration lower than 10-12 mol?L-1,octreotide had no inhibitory effect on the growth of colonic cancer cell line SW480.The antiproliferative effect of octritide and 5-fluorouracil on SW480 cells was significantly stronger when used in combination than used alone(P