Use Density of Carbapenems and Bacterial Drug Resistance in 5 Consecutive Years / 中国药房

ABSTRACT

OBJECTIVE:To investigate the effect of the correlation between the use density of carbapenems and the bacterial drug-resistance.METHODS:The data including the use density of carbapenems in the ICU ward of a hospital,the categories of the related pathogenic bacteria and monitoring results on drug resistances in 5 consecutive years were collected for an analysis of the quantitative change in a corresponding stage.RESULTS:Non-fermentative Gram-negative bacilli(NFGNB) were prone resistant to carbapenems and the resistant rate fluctuated in relation to the use density of carbapenems.The Enterobacter had low resistance to carbapenems and was independent of the use density of carbapenems.CONCLUSION:The use density of carbapenems has a positive correlation with the resistance of NFGNB.Reasonable drug use density may slow down or reduce bacterial drug-resistance.