Clinical Study of Shengui Capsule as an Adjunctive Therapy for Severe Congestive Heart Failure / 中国药房

ABSTRACT

OBJECTIVE:To observe the clinical efficacy and safety of Shengui capsule in treating severe congestive heart failure(CHF).METHODS: 68 patients with severe CHF were randomly divided into 2 groups34 patients(control group) were treated with routine therapy(rest,oxygen inhalation,inotropic agents and diuretic agents,vasodilators and symptomatic treatment) for 4 weeks,and another 34 patients with routine therapy plus 0.9 g Shengui capsule tid for 4 weeks(trial group).HR,BP,ECG,CD(Color Doppler),ANF(atrial natriuretic peptide),electrolytes and SCr before and after treatment were compared between the two groups.RESULTS: The cardiac function was improved and ANF level was down-regulated in patients treated with Shengui capsule,showing significant difference as compared with control group(P