RP-HPLC Analysis and Pharmacokinetics Study of Serum Carthamin in Mice / 中国药房
China Pharmacy
; (12)2007.
Article
em Zh
| WPRIM
| ID: wpr-531471
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:To establish an RP-HPLC analysis of Carthamin in mice and to study its pharmacokinetics.METHODS:The serum concentration of Carthamin was determined by RP-HPLC.The blood concentration-time curve was established and the main pharmacokinetic parameters were computed.RESULTS:The linear range of Carthamin was 0.558~55.8 ?g?L-1(r=0.999 2),with the lowest limit of detection at 0.005 ?g?L-1Carthamin in vivo assumed two-compartment model and rapid absorption.CONCLUSION:The proposed method is simple,sensitive and reproducible,and it met the standard for pharmacokinetic study.
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Índice:
WPRIM
Idioma:
Zh
Revista:
China Pharmacy
Ano de publicação:
2007
Tipo de documento:
Article