Preparation and Pharmaceutic Property of Core-shell Nanocapsules Containing Nicardipine Hydrochloride / 中国药房
China Pharmacy
;
(12)2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-531493
ABSTRACT
OBJECTIVE:
To prepare core-shell nanocapsules loading nicardipine hydrochloride and to investigate its pharmaceutical characteristics.METHODS:
Core-shell nanocapsules were prepared using layer-by-layer electrostatic self-assembly technique. The indexes including the shape and particle size and the loaded drug amount of the nanocapsules were evaluated, and its accumulative release rates in artificial gastric juice and intestinal juice were computed and compared with those of its crude drug.RESULTS:
The results showed that the nanocapsules were spherical with a mean particle size of 200 nm and a maximum loaded drug amount of 2.512%. The drug release rate within 12 h reached 18.64% in artificial gastric juice and 70% in artificial intestinal juice, whereas within 3 h the drug release rate of its crude drug in artificial intestinal juice reached 87%.CONCLUSIONS:
The prepared core-shell nanocapsules containing nicardipine hydrochloride had a good pharmaceutical property.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2007
Tipo de documento:
Artigo
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