Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease
Experimental & Molecular Medicine
;
: 333-347, 2006.
Artigo
em Inglês
| WPRIM
| ID: wpr-53157
ABSTRACT
Inflammation, a self-defensive reaction against various pathogenic stimuli, may become harmful self-damaging process. Increasing evidence has linked chronic inflammation to a number of neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis. In the central nervous system, microglia, the resident innate immune cells play major role in the inflammatory process. Although they form the first line of defense for the neural parenchyma, uncontrolled activation of microglia may directly toxic to neurons by releasing various substances such as inflammatory cytokines (IL-1beta, TNF-alpha, IL-6), NO, PGE
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doença de Parkinson
/
Transdução de Sinais
/
Citocinas
/
Complexo AIDS Demência
/
Microglia
/
Mediadores da Inflamação
/
Metaloproteinase 3 da Matriz
/
Metaloproteases
/
Encefalite
/
Alfa-Sinucleína
Tipo de estudo:
Estudo de etiologia
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2006
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS