Clinical Strategies to Develop Transplantation Tolerance / 한양의대학술지
Hanyang Medical Reviews
; : 70-76, 2006.
Article
em Ko
| WPRIM
| ID: wpr-53158
Biblioteca responsável:
WPRO
ABSTRACT
The development of immunosuprressants has had a significant influence on inhibition of acute allograft rejection. However, long-term graft survival has not been achieved by immunosuppressants, probably because of their nonspecific suppression of T cell activity and nonimmune side effects. The ideal way to overcome the limitations of current immunosuppressants is to induce allograft-specific immune tolerance. Transplant immunologists are exerting their efforts in achieving transplantation tolerance using four different approaches; costimulatory blockade, mixed hematopoietic chimerism, T cell depletion, and regulation by regulatory T cells. It is expected that transplantation tolerance will soon be established as a standard immunosuppressive regimen with little side effects in preventing and reversing allograft rejection.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Linfócitos T Reguladores
/
Tolerância ao Transplante
/
Quimerismo
/
Aloenxertos
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Sobrevivência de Enxerto
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Tolerância Imunológica
/
Imunossupressores
Idioma:
Ko
Revista:
Hanyang Medical Reviews
Ano de publicação:
2006
Tipo de documento:
Article