Determination of Main Components in Minocycline Hydrochloride Sustained-release Tablets by HPLC / 中国药房
China Pharmacy
;
(12)2001.
Artigo
em Chinês
| WPRIM
| ID: wpr-532085
ABSTRACT
OBJECTIVE:
To establish an HPLC method for determining the content of main components in minocycline hydrochloride sustained-release tablets.METHODS:
The sample was separated on ODS-C_(18)column with the mobile phase consisted of 0.2 mol?L~(-1)ammonium oxalate-0.01 mol?L~(-1)edetate disodium-dimethylformamide-tetrahydrofuran (60018012080)at a flow rate of 1.5 mL?min~(-1).The detection wavelength was set at 280 nm and the sample volume was 20?L.RESULTS:
The linear range of minocycline was 0.05~0.5 mg?mL~(-1)(r=0.999 8)and the average recovery was 99.11%,RSD=0.5%.CONCLUSIONS:
This method was proved to be accurate and reliable,sensitive and reproducible,and it can be used for determining the content of this tablets.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2001
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS