Vascular Stimulating Effect of Sodium Ozagrel for Injection:An Empirical Study / 中国药房

ABSTRACT

OBJECTIVE:To observe the stimulating effect of instilled sodium ozagrel for injection on rabbits'auricular vein.METHODS:Rabbits'auricular veins were assigned to receive sodium ozagrel for injection(19.0 mL?kg~(-1))or 5% glucose injection(19.0 mL?kg~(-1))q.d for 7 days by instillation.The rabbits were executed at 24 h and 72 h respectively after the last infusion,with rabbits'auricular blood vessel samples taken at the distance of 1 cm and 5 cm distal from injection site for histopathologic examination.RESULTS:Histopathologically,the rabbits treated by sodium ozagrel for injection(19.0 mL?kg~(-1))or 5%glucose injection showed similar changes in the skin and veins of the injection sites,and there were no abnormalities such as congestion,edema,induration and necrosis in both groups.CONCLUSION:No obvious stimulating effect on rabbits'auricular vein blood vessel was noted for sodium ozagrel for injection.