Bioavailability of Oral Drugs Following Chinese Materia Medica's Action on CYP3A4 and P-gp in Intestine / 中国药房
China Pharmacy
;
(12)2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-532462
ABSTRACT
OBJECTIVE:
To promote rational combined use of Chinese Chinese materia medica with western medicines.METHODS:
The mechanisms for Chinese materia medica and its chemical compositions to change the bioavailability of orally taken substrates by its inhibiting or inducing intestinal CYP3A4 and P-gp were summarized,and which were analyzed by combining the literature.RESULTS:
Fructus Schisandrae,Radix Angelicae Dahuricae,Radix Angelicae Sinensis,Rutaecarpine,Ginkgolide A etc could inhibit or induce the CYP3A4 enzyme;Radix Scutellariae,common St.Johnwort herb with root,Naringenin,Hypericin etc could inhibit or induce P-gp.The change of the parameters of the bioavailability of substrate drugs caused by Chinese materia medica and its chemical compositions through acting on intestinal CYP3A4 and P-gp could influence the drug safety and efficacy.CONCLUSION:
Clinicians and pharmacists should attach importance to the drug interactions in the concomitant use of Chinese traditional medicines and western drugs so as to promote rational drug use.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2005
Tipo de documento:
Artigo
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