Analeptic Action of Xingnaojing Injection in Patients Undergoing Total Intravenous Anesthesia / 中国药房

ABSTRACT

OBJECTIVE: To investigate the analeptic action of Xingnaojing injection(XNJI) in patients undergoing total intravenous anesthesia and the possible mechanism.METHODS: 60 patients undergoing selective abdominal operation with tracheal intubation(scored grade Ⅰ or grade Ⅱ using ASA score) were transferred to post-anesthctic ICU(PACU) after surgery and randomly divided into two groups of 30 each X group(XNJI 0.5 mL?kg-1) and C group(control group).The X group received XNJI(0.5 mL?kg-1) by drip infusion within 10 minutes,while C group received same amount of normal saline.The vocal reaction recovery time,autonomous breath recovery time,extubation time and duration of PACU stay were recorded.The mean arterial pressure(MAP),heart rate(HR),the concentrations of Epinephrine(E),and Norepinephrine(NE) and ?-endorphin(?-EP) in arterial blood were detected at 0,5,15,30 and 45 minutes before and after medication.RESULTS: No significant differences were noted for X group in hemodynamics parameters after medication as compared with before medication,but significant differences were noted for C group at 30 min and 45 min when compared with before medication or compared with X group at the same different time points.The vocal reaction recovery time,autonomous breath recovery time,extubation time and the duration of PACU stay were all significantly shorter in X group than in C group(P