Preparation of Oxymatrine Enteric-coated Pellets / 中国药房
China Pharmacy
; (12)2005.
Article
em Zh
| WPRIM
| ID: wpr-532778
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: To prepare Oxymatrine enteric-coated pellets.METHODS: The coating conditions such as the rotation speed,the coating temperature as well as the pressure of spray gun were optimized through single factor experiment;the properties of different coating solutions of resins were compared to optimize the coating material.The enteric-coated pellets were prepared by bed coating technology.The coating effect was evaluated by the dissolution in vitro. RESULTS: The optimal coating conditions were as follows: the rotation speed of the coating pan was 50 r?min-1,the coating temperature was 30 ℃,the pressure of spray gun was 0.10 MPa;the coating material was polyacrylic resin(Huzhou Ⅲ).The in vitro dissolution of the enteric-coated pellets prepared by the bed coating technology met the requirements specified in the Chinese Pharmacopeia(2005 edition).CONCLUSION: By using the bed coating technology,the enteric-coated pellets with good dissolution in vitro can be obtained.
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Índice:
WPRIM
Idioma:
Zh
Revista:
China Pharmacy
Ano de publicação:
2005
Tipo de documento:
Article