Efficacy of Reduced Glutathioue plus Xiangdan Injection for Anti-Tuberculosis Drug-induced Hepatic Lesion / 中国药房

ABSTRACT

OBJECTIVE:To observe the therapeutic efficacy of reduced glutathioue plus Xiangdan injection for anti-tuberculosis drug-induced hepatic lesion. METHODS:A total of 75 patients with anti-tuberculosis drug-induced hepatic lesion were randomly divided into two groups38 cases (trial group) were assigned to receive reduced glutathioue (1.2 g) that was added into normal saline(250 mL) by iv gtt q.d plus Xiangdan injection (20 mL) that was added into 10% glucose injection (250 mL) q.d by iv gtt;37 cases(control group)received potassium magnesium injection (20 mL)which was added into 10% glucose injection(250 mL) q.d by iv gtt. After treatment for 4 weeks,the liver function parameters and the total effective rates in two groups were measured. RESULTS:Compared with control group,the liver function had a significantly better improvement in trial group (P