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Quantitative Evaluation of Infectivity Change of Cryptosporidium parvum after Gamma Irradiation
The Korean Journal of Parasitology ; : 7-11, 2009.
Artigo em Inglês | WPRIM | ID: wpr-53286
ABSTRACT
Cryptosporidium parvum is a well-known waterborne and opportunistic intracellular protozoan parasite that causes diarrheal illness. In this study, we quantitatively investigated reduction of the infectivity of C. parvum after gamma irradiation and repair of the infectivity during incubation time after irradiation. C. parvum oocysts were subjected to gamma irradiation at various doses (1, 5, 10, and 25 kGy), and the in vitro infectivity was measured by real-time PCR every day up to 7 days after irradiation. The in vitro infectivity of C. parvum on human ileocecal adenocarcinoma cells (HCT-8) was effectively reduced (> 2 log(10)) by irradiation at 10 kGy or more. However, in the experiment to find out repair of the infectivity, recovery was not noted until day 7 post-incubation.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Virulência / Sobrevivência Celular / Cryptosporidium parvum / Criptosporidiose / Oocistos / Linhagem Celular Tumoral / Raios gama / Camundongos Endogâmicos C57BL Limite: Animais / Feminino / Humanos Idioma: Inglês Revista: The Korean Journal of Parasitology Ano de publicação: 2009 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Virulência / Sobrevivência Celular / Cryptosporidium parvum / Criptosporidiose / Oocistos / Linhagem Celular Tumoral / Raios gama / Camundongos Endogâmicos C57BL Limite: Animais / Feminino / Humanos Idioma: Inglês Revista: The Korean Journal of Parasitology Ano de publicação: 2009 Tipo de documento: Artigo