Mechanism of Antiemetic Effect of Celecoxib on Cisplatin-induced Delayed Emesis in Rats / 中国药房
China Pharmacy
;
(12)2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-532960
ABSTRACT
OBJECTIVE:
To study the action mechanism and effect of celecoxib on cisplatin-induced delayed emesis in rats.METHODS:
The rats were divided into control group,cisplatin group,and celecoxib group(cisplatin plus celecoxib).Kaolin intake in the rats after administration of corresponding drugs was observed.Levels of 5-HT and its metabolite 5-HIAA in intestinal tissues,and the activities of tryptophan hydroxylase(TPH)and monoamine oxidase(MAO)were determined,and the morphological changes of the intestinal tissues were observed.RESULTS:
In cisplatin group compared with control group,the Kaolin intake increased significantly(P
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2007
Tipo de documento:
Artigo
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