Effect of Lianggesan on T Helper Cell Shift in Rats with Acute Lung Injury Induced by Endotoxin / 中医杂志

ABSTRACT

Objective To investigate the molecular mechanism of inflamation development and anti-inflamation response of Lianggesan Decoction(Decoction for cooling the chest) on endotoxin-induced acute lung injury rats. Methods The rat models with acute lung injury were made by lipopolysaccharide(LPS) through intravenous injection.The high,middle and low dosage of Lianggesan Decoction were given by gastric perfusion and compared with dexamethasone(DXM).The contents of Th1 and Th2 in peripheral blood and bronchoalveolar lavage fluid(BALF) were measured at different time points to observe the changes in Th1/Th2.Results In the model group,Th1/Th2 in peripheral blood and BALF was gradually lowering,the difference was significant compared with those of the blank group(P