Preparation and Quality Control of Granisetron Hydrochloride Nasal Spray / 中国药房

ABSTRACT

OBJECTIVE:To prepare granisetron hydrochloride nasal spray and establish a method for its quality control. METHODS: Granisetron hydrochloride nasal spray was prepared using granisetron hydrochloride as chief ingredient and its content was determined by UV spectrophotometry. RESULTS: Spray appeared as colorless or yellowish supernatant liquid and it was up to the standard specified in Chinese Pharmacopeia (2005 edition). The linear range of granisetron hydrochloride was 105.9～635.4 ?g?mL-1 (r=0.999) and its average recovery rate was 100.1% (RSD=0.4%). CONCLUSION: The preparation is simple and feasible in preparation process and its quality is controllable.