Effects of Valsartan on Expression of PAI-1 in Renal Tissue in Patients with CKD / 中国药房

ABSTRACT

OBJECTIVE:To evaluate the expression on plasminogen activator inhibitor-1 (PAI-1) in the human renal biopsy of patients with CKD and analyze its clinical significance.METHODS:The expression of PAI-1 in 63 specimens of patients with CKD(CKD group) and 19 normal renal tissue(Control group) were detected by immuno-histochemistry.The expression of PAI-1 in the normal renal tissue were compared with the each phase CKD group.Meanwhile,The expression of PAI-1 in 16 patients with CKD treated by valsartan were compared with 47 cases not treated.RESULTS:Compare with the control group,the expression of PAI-1 in each phase CKD group was respectively drastically increased (P