Effects of Folium Crataegi Water Extract on the Contractility of Isolated Gastric and Intestinal Muscle Strips in Rats / 中国药房

ABSTRACT

OBJECTIVE: To study the effects of Folium Crataegi water extract on contractility of isolated gastric and intestinal smooth muscle strips in rats. METHODS: The effects of Folium Crataegi water extract on the contractility of isolated rat gastric and intestinal smooth muscle strips in the presence of normal Krebs’ solution, acetylcholine or atropine were investigated. RESULTS:Folium Crataegi water extract (5～20 mg?mL-1)significantly enhanced the contractility of rat gastric and intestinal smooth muscle strips in a dose-dependent manner, and Folium Crataegi water extract (20 mg?mL-1) could enhance the intensive contraction induced by acetylcholine and antagonize the relaxation of intestinal smooth muscle induced by atropine. CONCLUSION:Folium Crataegi water extract has remarkable stimulation on the contractility of isolated rat gastric and intestinal smooth muscle strips.