Role of glycogen synthase kinase-3? signal molecule in myocardial hypertropy / 中国病理生理杂志

ABSTRACT

Glycogen synthase kinase-3? (GSK-3?) is a serine/threonine protein kinase,which takes part not only in glycogen metabolism,but also in cell proliferation,differentiation and apoptosis. GSK-3? is inhibited by growth factors and hypertrophic stimuli through phosphorylation of its N-terminal end serine (Ser9) residue. It is also activated by phosphorylation of its tyrosine (Tyr216) residue. GSK-3? is profoundly inactivated in mice with hypertrophic cardiomyopathy (HCM) and plays a secondary role in myosin heavy chain mutation. However,the role of GSK-3? in HCM was controversial. Recent studies have demonstrated that the activation of GSK-3? inhibits the myocardial hypertrophy,and is regulated by Wnt/Frizzld and PI3-K/Akt signaling pathways. This article introduces the molecular role of glycogen synthase kinase-3? signaling in myocardial hypertrophy and the different pathways on the activity of glycogen synthase kinase-3? (GSK-3?)