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Formula Improvement and Quality Control of Urea Cream / 中国药房
China Pharmacy ; (12)2005.
Artigo em Chinês | WPRIM | ID: wpr-533802
ABSTRACT

OBJECTIVE:

To improve the formula of urea cream and establish its quality control methods.

METHODS:

The matrix component of formula was adjusted to prepare O/W matrix.Prednisone was added into matrix to prepare urea cream;UV spectrophotometry was applied to determine the content of urea and evaluate the quality of preparation and the stability of 3 batches of samples setting for 40 days under different conditions.

RESULTS:

The preparation was white cream and its inspection results were in line with the standards stated in Chinese Pharmacopoeia(2005 edition).The linear range of urea was 30.5~180.2 ?g?mL-1(r=0.999 0) with an average recovery of 99.68%(RSD=0.49%).The quality of 3 batches of samples kept stable during observation.

CONCLUSION:

Improved formula is reasonable,simple in preparation technology and quality control.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: China Pharmacy Ano de publicação: 2005 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: China Pharmacy Ano de publicação: 2005 Tipo de documento: Artigo