Clinical Efficacy of Granisetron Combined with Lidocaine Pretreatment in Minimizing Propofol Injection Pain and Vomiting / 中国药房
China Pharmacy
; (12)2005.
Article
em Zh
| WPRIM
| ID: wpr-533932
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:To observe clinical efficacy of specific 5-HT receptor antagonist granisetron combined with intravenous local anesthetic lidocaine pretreatment in minimizing propofol injection pain. METHODS:400 selective patients with laparoscopic cholecystectomy randomized into control group(group A),lidocaine group(group B),granisetron group(group C)and lidocaine combined with granisetron group(group D),n=100. Group A were treated with 3 mL normal saline and group B 20 mg lidocaine,group C 2 mg granisetron,group D 2 mg granisetron and 20 mg lidocaine. After 1 min the tourniquet released and a quarter of expected amount of propofol was given. Pain score of injection site was recorded. RESULTS:As group B、C and D,case number of injection nonpain in group A was higher than that of injection pain. There were statistical significance in the difference of case number and degree of injection pain among those groups(P
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1
Índice:
WPRIM
Tipo de estudo:
Clinical_trials
Idioma:
Zh
Revista:
China Pharmacy
Ano de publicação:
2005
Tipo de documento:
Article