Preparation and Quality Standard of Bifonazole Hollow Effervescent Suppository / 中国药房
China Pharmacy
;
(12)2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-533960
ABSTRACT
OBJECTIVE:
To prepare bifonazole hollow effervescent suppository and establish its quality standard.METHODS:
Bifonazole hollow effervescent suppository was prepared by hot-melting method, 38-type semisynthetic glyceride as the base material, NaHCO3 and citric acid as the effervescent agent, bifonazole as main ingredient. UV spectrophotometry was used for the content determination of bifonazole.RESULTS:
The weight of prepared suppository was about 2.3 g and mean size of maximal foaming capacity were all above 8 mL. The linear range of bifonazole were 1.015~10.15 ?g?mL-1(r=0.999 9) with an average recovery of 99.74% (RSD=1.28%).CONCLUSION:
The established preparation is simple, practical and up to the standard. The content determination method is precise and accurate.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2005
Tipo de documento:
Artigo
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