Signal transduction pathways involved in the pathogenesis of autosomal dominant polycystic kidney disease / 中国病理生理杂志

ABSTRACT

Autosomal dominant polycystic kidney diseases are a large family of inherited diseases,which are characterized by the development of multiple renal cysts of tubular epithelial cell origin. Progressively enlarging cysts compromise normal renal parenchyma,reduce renal function and lead to renal failure. This review article summarizes recent literatures on the intracellular calcium homeostasis and signaling involving cAMP,EGFR and Ras/ERK,Wnt,m-TOR,as well as JAK-STAT,in the pathogenesis of polycystic kidney disease.