Your browser doesn't support javascript.
loading
Study on Co-grinding Method Improving the Dissolution Rate of Nitrendipine in Vitro / 中国药房
China Pharmacy ; (12)2005.
Artigo em Chinês | WPRIM | ID: wpr-534119
ABSTRACT

OBJECTIVE:

To improve the dissolution rate of nitrendipine in vitro using co-grinding method.

METHODS:

Single-factor test was adopted to detect effect of phases of co-grinding,category of excipients (MCC,PVPk30,HPC,HPMC),time (0,10,20,30,40,50,60 min) of co-grinding and ratio of principal component to excipients (1 ∶ 1,1 ∶ 2,1 ∶ 3,1 ∶ 4,1 ∶ 5,1 ∶ 6,1 ∶ 7,1 ∶ 8,1 ∶ 9) on in vitro dissolution of nitrendipine power and tablet.

RESULTS:

The condition of co-grinding method was as follows dual co-grinding phase,HPC or MCC as excipients,co-grinding time of 40 min,ratio of principal component to excipients was 1 ∶ 4.Accumulative dissolution rate of nitrendipine powder was more than 80% within 10 min and that of nitrendipine tablet was more than 80% within 40 min.

CONCLUSION:

Co-grinding method can improve the dissolution rate of poorly water-soluble nitrendipine in vitro under suitable condition.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: China Pharmacy Ano de publicação: 2005 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: China Pharmacy Ano de publicação: 2005 Tipo de documento: Artigo