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Study on the Influence Factors for the Preparation of Reverse Microemulsions and the Optimization of Its Formula / 中国药房
China Pharmacy ; (12)2007.
Artigo em Chinês | WPRIM | ID: wpr-534263
ABSTRACT

OBJECTIVE:

To study the effect of oil phase,emulsifier and drugs on reverse microemulsion.

METHODS:

Pseudo-ternary phase diagram was adopted to study the effect of Span-80/Tween-80(emulsifier),thymopentin(model drug), long-chain glyceride,medium-chain glyceride,non-glyceride(oil phase).on the preparation of reverse microemulsions.Optimal formula of reverse microemulsions was selected.

RESULTS:

The largest water-in-oil(W/O)area was obtained in reverse microemulsion which was prepared using medium-chain glyceride as oil phase.Final formula was confirmed and contained distilled water/ Span-80/Tween-80/caprylic/capric triglyceride(2∶3∶6∶9).In addition,thymopentin was incorporated into the aqueous phase.

CONCLUSIONS:

The preparation of reverse microemulsions will be influenced by emulsifier,constitution of oil phase and drug.The influence factors for the actual preparation of reverse microemulsions should be optimized.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo prognóstico Idioma: Chinês Revista: China Pharmacy Ano de publicação: 2007 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo prognóstico Idioma: Chinês Revista: China Pharmacy Ano de publicação: 2007 Tipo de documento: Artigo