Study on Hemostatic Effects of Qishu Gongxuening Granules / 中国药房

ABSTRACT

OBJECTIVE: To study the hemostatic effects of Qishu gongxue granules. METHODS: Kunming mice and Wistar rats were randomly divided into five groups, i.e. normal control group, Fuke zhixuening group and Qishu gongxuening granules high-dose, medium-dose and low-dose groups. The change of coagulation time was compared among five groups. The value of PT and APTT were determined. Platelet aggregative function in rats was detected. RESULTS: Qishu gongxuening granules could reduce coagulation time of model mice and the level of PT and APTT in rats while it enhanced platelet aggregative function in rats. CONCLUSION: Qishu gongxuening granules can reduce coagulation time and it can be used for uterine bleeding. Hemostatic mechanism is associated with the production of plasmozyme and thrombokinase in the coagulation of blood and platelet aggregative function.