Antitumor and Antimetastasis Activity of LAK cells / 中国免疫学杂志

ABSTRACT

It has been shown that rat splenocytes incubated in IL-2 beoome lytic for WBT-2M fibrosarcoma cells of WKA rats and for SST-2 mammary carcinoma cells of SHR rats. We have performed the adoptive transfer of such LAK cells in WBT-2M and SST-2 met astasis models to test their in vivo efficacy. The LAK cells infused i. v. into WKA rats with WBT-2M fibrosarcoma and into SHR rats with SST-2 mammary carcinoma, led to marked decrease in the number of pulmonary metastatic nodules and to improve the survival of animals bearing SST-2. The combination of LAK cells and IL-2 provided a more effective antimetatic activity than LAK alone. T