A CLINICAL STUDY OF RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM IN EPIDEMIC HEMORRHAGIC FEVER / 西安交通大学学报(医学版)

ABSTRACT

The kinetic changes of the renin-angiotensin-aldosterone system (RAAS) were studied in 54 cases of epidemic hemorrhagic fever (EHF). It was found that plasma angiotensin Ⅱ (A T-Ⅱ) levels began to increase during the febrile period, reached the peak values during the hypotensive or oliguria period, and then dropped gradually during the polyuria period. However, the plasma angiotensin Ⅰ (AT-Ⅰ) levels decreased markedly lower in patients at the hypotensive or oliguria slage than in those at other stages. The plasma aldosterone (ALD) increased, corresponding to AT-Ⅱ during the hypotensive or oliguria period. The above changes were parallel to the severity of the disease and the quantity of BUN. From the results of our studies, it is concluded that the increased plasma AT-Ⅱ concentration and the activation of RAAS are related to hypovolemia and may be the most important factor of acute renal failure. Therefore, it is critical treatment at the early stage of EHF to maintain the equilibrium of body fluids and to resist the effects of activated RAAS.