MUSCULAR METABOLISM IN LOW SE CHILDREN / 西安交通大学学报(医学版)

ABSTRACT

A series of etiological investigations were made on muscular metabolism in low Se children and rats, including (1) low Se environment and low Se state in children, (2) moasurement of some biochemical indexes concerning muscular metabolism (selenium, creatine, ereatinine, phosphate, CPK, etc.), (3) Se supplemented experiment on children in low Se state, (4) experimental study on Se deficiency and Se supplemented dietary in rats, (5) patho-histological findings on the muscular tissues of children with KBD, and (6) effect of Se deficiency on muscular metabolism in children. The results show that there may be a causal relationship between Se deficiency in environment and muscular metabolism di- sturbance in low Se children. A hyphothesis on the disturbance of energy metabolism in mitochondria caused by Se deficiency is put forward that Se deficiency may blunt creatinephosphate synthesis in mitochondria and cause lesions in the mitochondrial structure, which was different from the antioxidant fiction. There is a marginal deficiency in Se for children in this paper, i.e. to take more than 20 ?tg Se/day is necessary. We suggest that muscular atrophy in low Se children be precisely designated by the name of "endemic Seresponsive muscular dystrophy".