ELECTROPHYSIOLOGICAL EFFECTS OF MGSO_4 ON OUABAIN INDUCED AUTOMATICITY OF GUINEA PIG HEART / 西安交通大学学报(医学版)

ABSTRACT

The effects of MgSo_4 on the automaticity of the ventricular muscles induced by ouabain in guinea pig were studied using a glass incroelectrode technique, The results showed (1)MgSo_4 (2～4mM)could inhibite the papillary muscle oscillatory afterpontial (OAP) of the guinea pig induced by ouabin (0.4?M); (2)2～4 mM of MgSo_4 could inhibite papillary muscle spontaeus electric activity frequeney induceb by 0.8?M ouabain and cause slop of diastolic depolarization to decrease; (3) When MgSo_4 and ouabain were pergused at the same time ventricular papillary OAP and spontaneous electric activity could not be induced. The results indicate that MgSo may prevent or cure oubain arrhythmias.