INFLUENCE OF SB ON PHARMACOKINETICS AND THE ANTI-INFLAMMATORY ACTION OF ASP IN A LARGE DOSE / 西安交通大学学报(医学版)

ABSTRACT

Influence of Sodium Bicarbonate (SB) in several doses on some pharmacokinetic parameters and the anti-inflammatory action of Aspirin (ASP) in a large dose was studied in rats of experimental inflammatory model. It was showed that SB significantly reduced the Tp, T_(1/2), AUC and increased the Ke, Cmax of plasma salicylic acid (SA). The anti-inflammatory effect of ASP was diminished as well. All of the changes, were enhanced as the doses of SB increased. The results in this paper suggested that combining ASP with SB in antirheumatic therapy might be an unreasonable regime.