INITIAL USE OF MONOCLONAL ANTIBODIES (McAbs) FOR THE TYPING OF ACUTE NON-LyMPHOID I.EUKEMIA(ANLL) AND CHRONIC MyELOCyTIC LEUKEMIA(CML) / 西安交通大学学报(医学版)

ABSTRACT

The leukemic cellular surface antigens of 45 cases for ANLL and 36 cases of CML were detected and classified with a series of the domestic McAbs by immunoflurescent technique. The immunophenotype of ANLL was compared with its cellular morphologic classification. The difference of the surface antigens between the CML instable phase and the CML in blast crisis was analyzed. Four cases of acute leukemias (AL) which could not be classified morphologically were classified by McAbs. FAB M_1～M_5 could be divided into 3 phenotype groups myeloblastic, promylocytic and promoncytic phenotype. The immunophenotype of ANLL tended to agree with its cellular morphologic classification. All 28 cases of CML in stable phase reacted with a neutrophil-McAb. However, there was no this antigen expression in 8 cases of CML in blast crisis. The immunophenotype of 4 cases of AL could be made with McAbs . Of these 4 cases. 3 were AL and 1 ANLL.