THE RELATIONSHIP BETWEEN TRAb AND THYROID STATUS, REMISSION OR RELAPSE OF GRAVES' DISEASE / 中华内分泌代谢杂志

ABSTRACT

TSH receptor antibodies (TRAb) were measured using radioreceptor assay in 305 patients with Graves' disease. The results of this study showed that the positive rate (94.7%) and inhibition tate (47.1?2.2 %, sx) of TRAb in hyperthyroid group were much higher than those in euthyroid group. TRAb activity was detectable in 96.9% of 32 patients with relapsed Graves' disease and the inhibition value was 50.1? 26.2%. Both values were significantly higher than those in patients who were in remission. 38 euthyroid patients were followed-up for 8-30 months after stopping the antithyroid drug. The results showed that 12 out of 16 patients who were TRAb positive relapsed, while 22 patients who were negative for TRAb remained in remission except 5 patients. The TRAb activity was higher after relapse than before (P