Effect of Early Stage Shock in Combined Radiation—Burn on Whole Body and Intestinal Epithelium of Mice / 中华创伤杂志

ABSTRACT

Compared study of the early shock stage effects on whole body and intestinal epithelium was taken among radiation injury (12.16Gy irradiation of a ~(60)Co source), burns (5%, 10%, 15%, 25%TBSA Ⅲ?) and combined radiation-burn injury animals. Seven hundred and fifty mice were examined totally. The incidence of severe shock increased as the extent of burn area increased. The early burn shock was the most important cause of death in combined injury animals before 48h postinjury, and represented 8 special feature of combined effects. Early shock could be prevented and early stage death peak disappeared through fluid replacement to the combined injury animals, meanwhile, severe damage of intestinal epithelium resulted by the shock mitigated. Thus, if the shock was effectively treated, further treatment and regeneration of intestinal epithelium could become possible.