ANALYSIS OF ESTROGEN AND PROGESTERONE LEVELS DURING MENSTRUAL CY-CLE IN PATIENTS WITH FIBROCYSTIC DISEASE OF BREAST / 中华内分泌代谢杂志

ABSTRACT

The blood and urine estrogen (E2) and progesterone (P) were measured in 133 patients with fibrocystic disease (FCD) of breast and 17 healthy subsjects during menstrual cycle phases. According to the characteristics of the secretion, the patients were divided into five types. Type A (54 patients) The secretion peak of E2 and P appeared beforehand and secretion of P was prolonged and E2 decreased significantly in ovulatory phase. Type B (16 patients) The secretion peak of E2 disappeared in ovulatory phase although the secretion of P was normal. Type C (16 patients) The secretion peak of P deferred its disappearance and maintained at higher level till pre-menstrual period and sc did E2 the secretion of E2 decreased in ovulatory phase. Type D (41 patients) The secretion peak of E2 in ovulatory phase was normal but could not return to normal level in pre-menstrual period, in the mean time the secretion of P also deferred its disappearance. Type E (6 patients) There was no secretion of P and the blood and urine concentrations of E2 deccreased in all phases. The average value of E2 in the patients with FCD was compared with that of healthy subjects. The concentration of E2 in all the patients increased in follicular and pre-menstrual phases. However, the concentration of E2 in ovulatory phase was much lower in the patients than in healthy subjects.