The relationship between the effect of carbamazepine on chromosome aberration rate and sister chromatid exchange frequencies and the folic acid in epileptic patients / 中华神经科杂志
Chinese Journal of Neurology
;
(12)1999.
Artigo
em Chinês
| WPRIM
| ID: wpr-535696
ABSTRACT
Objective To investigate the relationship between the mutagenicity of carbamazepine (CBZ) and folic acid (FA), and to explore the mechanism of CBZ teratogensis and the prevention effect of the folic acid. Methods Peripheral blood lymphocyte chromosome aberration rate (CAR), sister chromatid exchange (SCE)frequencies, and serum FA levels have been studied in 15 CBZ -treated epileptic patients, 15 CBZ plus FA-treated epileptic patients The untreated epileptic patients and the health subjects were served as controls Results CAR and SCE frequencies were significantly higher in CBZ group as compared with the CBZ plus FA group and the controls ( P
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Neurology
Ano de publicação:
1999
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS