A monoclonal antibody to common acute lymphoblastic leukemia antigen (CALLA) and its expression on several human tumor cell lines
Journal of Korean Medical Science
;
: 147-153, 1992.
Artigo
em Inglês
| WPRIM
| ID: wpr-53613
ABSTRACT
We describe a newly-made murine monoclonal antibody to the common acute lymphoblastic leukemia antigen (CALLA), named SHB-10. The antigen detected by SHB-10 has a molecular weight of about 105 kDa. This antibody is very similar to that of conventional anti-CD10 Ab on indirect flowcytometric analysis using lymphoid malignant cell lines and peripheral lymphocytes of acute lymphoblastic leukemia (ALL) patients. The binding of anti-CD10 to Daudi cell and peripheral lymphocytes of ALL patients is blocked by SHB-10. Thus this monoclonal antibody is thought to detect the CALLA. The distribution of antigen detected by SHB-10 on several cell lines of neuroectodermal tumor and lymphoid malignancy was analysed and a slight difference in their cell surface expression is observed when compared with that by conventional anti-CD10. Further biochemical analysis is now under way for a better characterization of this antigen.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Isotipos de Imunoglobulinas
/
Células Tumorais Cultivadas
/
Neprilisina
/
Antígenos de Diferenciação
/
Biomarcadores Tumorais
/
Citometria de Fluxo
/
Camundongos Endogâmicos BALB C
/
Anticorpos Monoclonais
/
Antígenos de Neoplasias
/
Neoplasias
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Journal of Korean Medical Science
Ano de publicação:
1992
Tipo de documento:
Artigo
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