Studies on the pharmacokinetics of the intravesical instillation of mucous adhesive anticancer agent hydroxypropylcellulose-mitomycin C / 中华泌尿外科杂志
Chinese Journal of Urology
;
(12)2000.
Artigo
em Chinês
| WPRIM
| ID: wpr-536325
ABSTRACT
Objective To study the drug retention of HPC MMC in bladder after intravesical instillation. Methods The pharmacokinetics of the intravesical mucous adhesive anticancer agent HPC MMC in urine and in tissue were comparatively studied with conventional mitomycin C aqueous solution(S MMC) by means of animal experiment. Results After instillation, the half life of MMC in urine in the 2 groups was 2.61 h and 0.56 h and in tissue 2.33h and 0.46 h respectively. Conclusions Suggesting that HPC MMC remained longer within the urinary bladder. It may be therapeutically more efficient.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Urology
Ano de publicação:
2000
Tipo de documento:
Artigo
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