Effects of Fenvalerate on Humoral Immunity and Sex Hormone Level in Premature Female Rats / 环境与健康杂志

ABSTRACT

ve To understand the effects of fenvalerate on the secretion of sex hormone and humoral im-mune function and to explore their mechanism. Methods 20 female SD rats aged 4 weeks were randomly divided into 2 groups fenvalerate group treated by peritoneal injection with 1/10 LD50 of fenvalerate and control group treated with disinfected bean oil. The serum specimens were obtained from rats of 2 groups at the 4th week after the peri-toneal injection. The levels of interleukin-6 (IL-6). tumor necrosis factor-? (TNF-?) and immunoglobulin G (IgG) in serum were measured with ELISA. The levels of 17?-estradiol (E2) and testosterone (T) were measured with ra-dioimmune assay. Results The levels of IL-6, TNF-? and IgG in serum specimens of rats were 2.244 ng/ ml, 0.360 ng/ml and 4.928?g/ml for fenvalerate group, 2.805 ng/ml, 0.439 ng/ml and 3.825?g/ml for control group respec-tively. The levels of IL-6 and TNF-? in serum specimens of rats were significantly lower than those of control group (P 0.05. Conclusion Fenvalerate could effect the hu-moral immune system and the levels of sex hormones. Its passible mechanism was that fenvalerate could affect the levels of sex hormones first, and then the whole immune system further.