Curcumin inhibits leukemia cell line HL_60 /ADR / 中国免疫学杂志

ABSTRACT

Abstract Objective:To explore the suppression of curcumin on leukemia cell line HL60/DAR. Methods: The suppression of curcumin onleukemia cell line HL60/DAR was studied by MTT;the apoptosis was studied by flow cytometric Annexin V/PI dual labeling technique and fluo-rescence microscope;the change in apoptosis related gene bcl-2 was studied by flow cytometry.Results: CUrcumin suppressed the growth ofHL60/DAR obviously IC50 were 8.94,5.2l,3.82 ?g/ml for 24,48,72 h respectively. Curcumin induced Hl60/DAR cells to apoptosisdeath. CUrcumin suppressed the expression of bcl-2. Conclusion: Curcumin can suppress the growth of HL60/DAR cells.