Efficacy of Q-switched Alexandrite laser in seborrheic keratosis / 中华医学美学美容杂志

ABSTRACT

Objective Seborrheic keratosis are very common dermatosis occurred in the fourth to fifth decade. Recently, some encouraging results in the treatment of melain-related lesions, such as Ota`s nevus, tatoos, cafe spots, have been obtained using the Q-switched Alexandrite laser, but no reports were found in treating seborrheic keratosis. Our purpose was to assess the clinical outcomes induced by the Q-switched Alexandrite laser at 752nm. Methods Total 119 cases of seborrheic keratoses , aged from 31-76years, were treated with the Q-switched Alexandrite laser (model HT-10, Cynosure Laser Corp, USA. wavelength 752nm, pulse width 45-75ns). The energy was adjusted to 7.1-8.5J/cm 2 according to the charateristics of the lesions. The interval of two treatment was 1.5-3 months. No special care was needed. Results Sixty-seven of the 119 patients were evaluated after treatment (men 15 cases, women 52 cases, aged from 31～71 years, and course from 1 to 21 years). All the patients were treated by 1-3 times. The number of cases treated by 1, 2, and 3 times was 50 (74.6 %), 14 (20.9 %) and 3 (4.5 %), respectively. The degree of clearing was complete clearing (17 cases, 25.4 %), significant improvement (25 cases, 37.3 %), moderate improvement (17 cases,25.4 %) and no change or mild improvement (8 cases,11.9%). The total rate of improment was 62.7%, while the improvement rate after 1 treatment was 58%. The efficacy was correlated with the area of the lesions. No side effects, such as hyperpigmentation and scars, were found. Conclusions This clinical data demonstrate the Q-switched Alexandrite laser is a safe and effective method for treatment of seborrheic keratosis and deserves to be used widely.