Relationship between thyrotropin receptor gene mutation and toxic multinodular goiter / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12)1985.
Artigo
em Chinês
| WPRIM
| ID: wpr-537875
ABSTRACT
DNA was extracted from thyroid nodular tissue in 16 patients with toxic multinodular goitor (TMG). After PCR, the product of PCR was sequenced, and 3 cases with point mutation (A1964T) and 2 cases with insertion mutation (a G was inserted after nucleotide 1928) in TSH receptor gene were found. It is postulated that these mutations may play an important role in the pathogenesis of TMG.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Endocrinology and Metabolism
Ano de publicação:
1985
Tipo de documento:
Artigo
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