Lung Lesion of Rats Exposed to Cooking Siritch Oil Fume / 环境与健康杂志

ABSTRACT

Objective To probe the lung lesion of rats inhaling cooking siritch oil fume(CSOF). Methods The male SD rats were randomly divided into exposure group and negative control group, 18 rats per group, then each group was randomly divided into 3 subgroups for dynamic observation, 6 rats per subgroup. The rats in exposure group were dynamicly inhaled with (44.44?18.68) mg/m3 CSOF and negative control group were dynamicly inhaled with fresh air at temperature of 20-22 ℃. The activities of superoxide dismutase (SOD) and the concentration of malondialdehyde(MDA) in serum and lung tissue, the activities of nitric oxide synthase (NOS) and the levels of nitric oxide (NO) in lung tissue were determined, the body weight and pathomorphological varians of lung tissue were observed in rats of exposure group and negative group at the 15th, 30th, 50th day of CSOF exposure. Results In the exposure group, the rats' body weights were lower than those in negative control group (P