Screening of the interaction protein with Wnt signaling molecular-TCF4 from renal carcinoma cDNA library by yeast two hybrid / 中华泌尿外科杂志
Chinese Journal of Urology
;
(12)2000.
Artigo
em Chinês
| WPRIM
| ID: wpr-538800
ABSTRACT
ObjectiveTo investigate the interaction pr otein with Wnt signaling molecular-TCF4 in renal carcinogenesis.Me thodsThe N terminal and DNA binding domain of human T cell factor 4 (TCF4ND, 1~495 aa) was used as a bait to screen the renal carcinoma cDNA libra r y by yeast two hybrid.Results51 positive colonies were fished out such as ?-catenin,TCF4,activating transcription factor 5(ATF5),and 2 unknown genes.ConclusionsIt is indicated that exten sive signaling cross-talks between Wnt and other signaling pathways might play an significant role in renal carcinogenesis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo diagnóstico
/
Estudo de rastreamento
Idioma:
Chinês
Revista:
Chinese Journal of Urology
Ano de publicação:
2000
Tipo de documento:
Artigo
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